Potassium Carbonate → HCID 21460400, compound

HRID 1941213Notes

Reaction equation

HRID 1941213 reaction equation
[Br:1][C:2]([CH3:7])([CH3:6])[C:3](Br)=[O:4].C([O-])([O-])=O.[K+].[K+].[CH2:14]([O:21][CH2:22][CH2:23][NH2:24])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>ClCCl>[CH2:14]([O:21][CH2:22][CH2:23][NH:24][C:3](=[O:4])[C:2]([Br:1])([CH3:7])[CH3:6])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 886852-Bromo-2-methylpropionyl bromideHCID 5338682-(Benzyloxy)ethanamine

Product 1

HCID 21460400HCID 21460400, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a mixture of 2-bromo-2-methylpropionylbromid (76 g), K2CO3 (55 g) and dichloromethane (700 ml) was added a solution of 2-benzyloxyethylamine (50 g) in dichloromethane (500 ml) at -10° C. After stirring at room temperature for 1.5 h the mixture was washed with water (500 ml) and dried (MgSO4). Evaporation of the solvents in vacuo afforded N-(2-benzyloxyethyl)-2-bromo-2-methylpropionamide as an oil: 104 g

Workup

  1. washwas washed with water (500 ml)
  2. dry with materialdried (MgSO4)
  3. customEvaporation of the solvents in vacuo

Sources & evidence

ORD record
ord-e1ee6438b2884132b6e3aebf6a86c571
Source dataset
uspto-grants-1997_12
Patent number
US05703087

Reaction notes

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