Carbon Dioxide → HCID 21460704, compound

HRID 1941429Notes

Reaction equation

HRID 1941429 reaction equation
[N+:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([Cl:14])=[C:10]([Cl:13])[CH:11]=2)[NH:6][C:5]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])([O-])=O.O.O.[Sn](Cl)Cl.C(=O)([O-])[O-].[K+].[K+].C(=O)=O>C(O)C.O.C(OCC)(=O)C>[NH2:1][C:4]1[C:12]2[C:7](=[CH:8][C:9]([Cl:14])=[C:10]([Cl:13])[CH:11]=2)[NH:6][C:5]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

8

Reactant 4

HCID 280Carbon DioxideHCID 11430Potassium CarbonateHCID 61436Stannous chloride dihydrateHCID 21460723HCID 21460723, compound

Product 1

HCID 21460704HCID 21460704, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

Dissolve 3-nitro-2-carbethoxy-5,6-dichloroindole (38.1 g) in ethanol (1 L) and add tin (II) chloride dihydrate (163 g). Warm to between 65° and 75° C. for 4 to 5 hours. Cool to room temperature and pour into a mixture of ethyl acetate (3 L) and water (2 L). Add solid potassium carbonate and stir occasionally until the carbon dioxide evolution ceases. Filter throught diatomaceous earth and separate the organic phase of the flitrate. Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.

Workup

  1. temperatureWarm to between 65° and 75° C. for 4 to 5 hours
  2. filtrationFilter
  3. customseparate the organic phase of the flitrate
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-ea8ca5c82eb7472a9fb2a7020d3d6617
Source dataset
uspto-grants-1997_12
Patent number
US05703107

Reaction notes

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