Water → HCID 70061333, compound

HRID 1941563Notes

Reaction equation

HRID 1941563 reaction equation
[NH2:1][N:2]=[CH:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:30])[CH2:12][CH2:13][C:14]([NH:16][CH:17]([C:24]#[C:25][CH2:26][N:27]=[N+]=[N-])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:15])=[CH:6][CH:5]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>C1COCC1>[NH2:1][N:2]=[CH:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:30])[CH2:12][CH2:13][C:14]([NH:16][CH:17]([C:24]#[C:25][CH2:26][NH2:27])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:15])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 131718659HCID 131718659, compound

Product 1

HCID 70061333HCID 70061333, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound can be prepared by treating the title compound of Example 85 with triphenylphosphine and water in THF as described in the literature [N. Knouzi, M. Vaultier, R. Carrie Bull. of Chem. Soc. France, 815 (1985)] which can afford the title compound directly. The product can be purified by reverse phase HPLC using the conditions of Example 1 to afford the title compound. The product can be verified by C NMR.

Sources & evidence

ORD record
ord-a68871fb30fb433186e6ac10a9f1e63a
Source dataset
uspto-grants-1997_12
Patent number
US05703125

Reaction notes

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