Hydrochloric Acid → Pyridine-2-carboxylic acid (3-amino-adamantan-1-yl)-amide

Temperature

90 °C

To a round bottom flask was added 3-[(pyridine-2-carbonyl)-amino]-adamantane-1-carboxylic acid (10.0 g, 33.3 mmol) and toluene (100 mL). To the suspension was added triethylamine (5.6 mL, 40 mmol) and the mixture was stirred for a few minutes until most of the solids were dissolved. To the mixture was then added diphenylphosphonic azide (7.9 mL, 37 mmol) and the reaction was stirred at room temperature for 1 hour. The reaction mixture was transferred to an addition funnel and added dropwise to a 3-neck round bottom flask equipped with a reflux condenser containing toluene (70 mL) heated at 90° C. After the addition, the reaction was stirred at 90° C. for two more hours, then allowed to cool down to room temperature. The reaction mixture was then slowly added to a flask containing 6.0 N aqueous hydrochloric acid (55 mL, 330 mmol) and stirred vigorously for 1 hour. The biphasic mixture was transferred to a separatory funnel and the toluene layer was discarded. The aqueous acidic layer was then slowly treated with solid sodium carbonate until a pH of 10 was obtained. The aqueous layer was transferred to a 500-mL separatory funnel and extracted with methylene chloride (3×100 mL). The combined organic layers were then washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to afford 8.38 g (93%) of the title compound, pyridine-2-carboxylic acid (3-amino-adamantan-1-yl)-amide, as a gummy foam. 1H NMR (300 MHz, CDCl3) δ 8.55-8.50 (m, 1H), 8.16 (d, J=7.9 Hz, 1H), 7.94 (br s, 1H). 7.84 (td, J=7.7, 1.7 Hz, 1H), 7.40 (ddd, J=7.6, 4.7, 1.3 Hz, 1H), 2.31-2.21 (m, 2H), 2.13-1.97 (m, 6H), 1.71-1.51 (m, 6H). ESI-MS m/z: 272 (M+H)+.

1. dissolutionwere dissolved
2. customThe reaction mixture was transferred to an addition funnel
3. additionadded dropwise to a 3-neck round bottom flask
4. customequipped with a reflux condenser
5. additionAfter the addition
6. stirringthe reaction was stirred at 90° C. for two more hours
7. temperatureto cool down to room temperature
8. additionThe reaction mixture was then slowly added to a flask
9. stirringstirred vigorously for 1 hour
10. customThe biphasic mixture was transferred to a separatory funnel
11. customwas obtained
12. customThe aqueous layer was transferred to a 500-mL separatory funnel
13. extractionextracted with methylene chloride (3×100 mL)
14. washThe combined organic layers were then washed with brine
15. dry with materialdried over sodium sulfate
16. filtrationfiltered
17. concentrationconcentrated under reduced pressure

ORD record

ord-f1c38ccb11ef4f43b7938ecd1febe021

Source dataset

uspto-grants-2013_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08389519B2