反应详情

To a suspension of 6-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester (150 mg, 0.47 mmol) in THF (1.5 mL) and methanol (0.5 mL) was added a solution of lithium hydroxide monohydrate (39.2 mg, 0.94 mmol) in water (1.5 mL) added and the resulting mixture stirred at room temperature for 1 h. The mixture was acidified to pH 4 with HCl (1 N) and cooled to 0° C. The precipitate was filtered off and dried to afford the title compound (134 mg, 93%) which was obtained as a white solid. MS: m/e=305.4 [M−H]+.

1. additionadded
2. temperaturecooled to 0° C
3. filtrationThe precipitate was filtered off
4. customdried