反应详情

A solution of 2.7 mL (18.75 mmol) of Et3N in 5 mL of 1,2-dichloroethane was added drop by drop under ice cooling to a suspension of 1.85 g (13.75 mmol) AlCl3 in 10 mL of dichloroethane. At room temperature a solution of 2.33 g (13.75 mmol) 2-aminoindane HCl (and Et3N for the solvation of the hydrochloride) and 1.16 mL (12.5 mmol) delta-valerolactone in 7.5 mL 1,2-dichloroethane was added to the mixture. After one hour of stirring at room temperature the mixture was quenched with ice water and stirred for another 30 minutes. The suspension was filtered by Celite. After adding of dichloromethane, separating of the organic layer, washing it with water, drying it with Na2SO4 and evaporating of the solvent, followed.

1. customwas quenched with ice water
2. stirringstirred for another 30 minutes
3. filtrationThe suspension was filtered by Celite
4. additionAfter adding of dichloromethane
5. customseparating of the organic layer
6. washwashing it with water
7. dry with materialdrying it with Na2SO4
8. customevaporating of the solvent