反应详情

温度

85 °C

To a solution of 4-bromo-2-chlorophenol (50 g) in N,N-dimethylformamide (DMF) (250 mL) stirred under nitrogen at room temperature was added K2CO3 (100 g) and 2-bromopropane (136 mL) in one charge. The reaction mixture was stirred at 85° C. for 16 h. After cooling the reaction, the reaction mixture was filtered, the solvent of the filtrate was removed in vacuo. The residue was dissolved in diethyl ether (300 mL), washed with water (6*100 mL), the organic phase was dried over MgSO4 and concentrated to give 4-bromo-2-chlorophenyl 1-methylethyl ether (D68) (56 g) as a yellow oil. δH (CDCl3, 400 MHz): 1.37 (6H, d), 4.52 (1H, m), 6.82 (1H, d), 7.29 (1H, m), 7.50 (1H, d).

1. additioncharge
2. temperatureAfter cooling
3. customthe reaction
4. filtrationthe reaction mixture was filtered
5. customthe solvent of the filtrate was removed in vacuo
6. dissolutionThe residue was dissolved in diethyl ether (300 mL)
7. washwashed with water (6*100 mL)
8. dry with materialthe organic phase was dried over MgSO4
9. concentrationconcentrated