Hydrochloric Acid → Carvone, (-)-

HRID 1942941노트

반응식

HRID 1942941 반응식
[CH3:1][C:2]1[CH2:7][CH2:6][C@@H:5]([C:8]([CH3:10])=[CH2:9])[CH2:4][CH:3]=1.Cl.CC1CC[C@@H](C(C)=C)CC=1.N(Cl)=[O:23].CN(C)C=O>C(O)(C)C.N([O-])=O.[Na+]>[CH3:1][C:2]1[C:7](=[O:23])[CH2:6][C@H:5]([C:8]([CH3:10])=[CH2:9])[CH2:4][CH:3]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 440917(+)-Limonene3회HCID 131730184Limonene nitrosochloride2회

생성물 1

HCID 439570Carvone, (-)-

시약·촉매·용매 2

HCID 3776Isopropanol용매3회HCID 23668193Sodium Nitrite용매

실험 절차

Synthesis of the exemplary Formula VI terpene compound L-Carvone (2-cyclohexen-1-one, 2-methyl-5-(1-methylethenyl)-(R); Millenium Chemicals) from D-limonene is described in Ikan, Natural Products—A Laboratory Guide pp. 151-155 (Academic Press, 1969), incorporated herein by reference. Briefly, a solution of D-limonene in isopropanol is cooled to below 10° C. Solutions of HCl in isopropanol and concentrated aqueous sodium nitrite are added dropwise to the D-limonene solution to generate limonene nitrosochloride. The limonene nitrosochloride and dimethylformamide is refluxed with isopropanol. After cooling, crystallization is induced and the precipitate filtered and washed with water. The resulting L-carvoxime is refluxed with 0.5 M oxalic acid and the mixture is steam distilled. The distillate is extracted with ether, dried over anhydrous magnesium sulfate, and the excess ether evaporated to leave L-carvone.

후처리

  1. temperatureAfter cooling
  2. customcrystallization
  3. filtrationthe precipitate filtered
  4. washwashed with water
  5. temperatureThe resulting L-carvoxime is refluxed with 0.5 M oxalic acid
  6. distillationdistilled
  7. extractionThe distillate is extracted with ether
  8. dry with materialdried over anhydrous magnesium sulfate
  9. customthe excess ether evaporated

출처 및 근거

ORD 기록
ord-ae746b11e20d4265a9a14da0316eb47f
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389730B2

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