反应详情

To a solution of isoxazol-3-amine (25.8 mg, 0.307 mmol) in THF (0.5 mL) was added 60% NaH (12.26 mg, 0.307 mmol). The mixture was stirred for 10 min and 5A (40 mg, 0.123 mmol) was added followed by DMF (0.5 mL). The mixture was stirred overnight. The solvent was removed under a stream of nitrogen and water was added. The resulting solid was collected by filtration, rinsed with water, and dried on vacuum to give the title compound as a yellow solid.

1. stirringThe mixture was stirred overnight
2. customThe solvent was removed under a stream of nitrogen and water
3. additionwas added
4. filtrationThe resulting solid was collected by filtration
5. washrinsed with water
6. customdried on vacuum