Potassium Carbonate → 7-pyridin-3-yl-1H-pyrido[2,3-b][1,4]oxazin-2-one

HRID 1943703Notes

Reaction equation

HRID 1943703 reaction equation
Br[C:2]1[CH:12]=[N:11][C:5]2[O:6][CH2:7][C:8](=[O:10])[NH:9][C:4]=2[CH:3]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[C:15](B(O)O)[CH:14]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O.C(#N)C>[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:2]2[CH:12]=[N:11][C:5]3[O:6][CH2:7][C:8](=[O:10])[NH:9][C:4]=3[CH:3]=2)[CH:14]=1

Participants

8

Reactant 4

HCID 11430Potassium CarbonateHCID 11776TriphenylphosphineHCID 27343783-Pyridinylboronic acidHCID 45901417-bromo-1H,2H,3H-pyrido[2,3-b][1,4]oxazin-2-one

Product 1

HCID 669367477-pyridin-3-yl-1H-pyrido[2,3-b][1,4]oxazin-2-oneYield 110%

Reagents, catalysts & solvents 3

HCID 167845palladium(II) acetateCatalystHCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

To 1.6 ml of acetonitrile/0.4 ml of distilled water, 7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2-one (100 mg, 0.436 mmol), 3-pyridine boronic acid (29.5 mg, 0.240 mmol), palladium acetate (4.9 mg, 0.0218 mmol), triphenylphosphine (11.4 mg, 0.0436 mmol) and potassium carbonate (45.2 mg, 0.327 mmol) were added and then stirred at 1000 for 10 hours. After completion of the reaction, the mixture was extracted with ethyl acetate, and the combined organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica eluting with a solvent of dichloromethane:methanol=50:1. The fractions containing the product were collected and evaporated to obtain 7-pyridin-3-yl-1H-pyrido[2,3-b][1,4]oxazin-2-one as brown oil (60 mg, 60%).

Workup

  1. customAfter completion of the reaction
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialthe combined organic layer was dried over anhydrous sodium sulfate (Na2SO4)
  4. filtrationfiltered
  5. customevaporated under reduced pressure
  6. customThe residue was purified by column chromatography on silica eluting with a solvent of dichloromethane
  7. additionThe fractions containing the product
  8. customwere collected
  9. customevaporated

Sources & evidence

ORD record
ord-30d4c4f192a24e6f89b6bf92465f8a33
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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