反应详情

A stirred solution of 7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione (10 g, 52 mmol) in anhydrous DMF (100 ml) was treated with K2CO3 (7.91 g, 57.2 mmol) and, after 10 minutes, BuI (6.51 ml, 57.2 mmol). After reacting for 2 days the reaction mixture was partitioned between 2M HCl (aq) and EtOAc. The organic layer was separated, washed with brine, dried (MgSO4) and concentrated in vacuo to give an off-white solid. This was washed with hot cyclohexane and dried under vacuum to give the title compound (8.87 g, 68%); m/z 249.3[MH+].

1. customthe reaction mixture was partitioned between 2M HCl (aq) and EtOAc
2. customThe organic layer was separated
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo
6. customto give an off-white solid
7. washThis was washed with hot cyclohexane
8. customdried under vacuum