Water → HCID 22997467, compound

HRID 1944112Notes

Reaction equation

HRID 1944112 reaction equation
C(N1[CH2:8][CH2:7][O:6]CC1)C.CN(C(ON1N=N[C:19]2[CH:20]=C[CH:22]=[CH:23][C:18]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.O.[CH3:32]N(C=O)C>>[CH3:20][CH2:19][CH2:18][CH2:23][CH2:22][CH2:7][CH3:8].[CH:7]([O:6][CH:23]([CH3:22])[CH3:18])([CH3:8])[CH3:32]

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 7525EthylmorpholineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Product 1

HCID 22997467HCID 22997467, compound

Procedure

To a mixture of the product of example 1i (220 mg) and the product of example 23a (145 mg) in DMF (1.5 ml) was added N-ethylmorpholine (100 μl) and TBTU (200 mg). The reaction mixture was stirred at room temperature for 2 h. Water (5 ml) was added, followed by filtration and drying of the precipitate. Trituration with heptane/diisopropylether afforded the product.

Workup

  1. filtrationfollowed by filtration
  2. customdrying of the precipitate

Sources & evidence

ORD record
ord-5e2aeadaa7d445388f4ecb98bd5b71ab
Source dataset
uspto-grants-2013_03
Patent number
US08394789B2

Reaction notes

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