Bromoacetyl bromide → HCID 66925877, compound

HRID 1944120Notes

Reaction equation

HRID 1944120 reaction equation
[Br:1][CH2:2][C:3](Br)=[O:4].[C:6]([N:10]([CH3:34])[C:11]([C:13]1[N:17]2[CH2:18][CH2:19][C:20]3[C:25]([C:16]2=[C:15]([C:29]2[S:30][CH:31]=[CH:32][CH:33]=2)[CH:14]=1)=[CH:24][C:23]([NH2:26])=[C:22]([O:27][CH3:28])[CH:21]=3)=[O:12])([CH3:9])([CH3:8])[CH3:7].CCN(C(C)C)C(C)C>ClCCl>[C:6]([N:10]([CH3:34])[C:11]([C:13]1[N:17]2[CH2:18][CH2:19][CH:20]3[CH:25]([C:16]2=[C:15]([C:29]2[S:30][CH:31]=[CH:32][CH:33]=2)[CH:14]=1)[CH:24]=[C:23]([NH:26][C:3](=[O:4])[CH2:2][Br:1])[C:22]([O:27][CH3:28])=[CH:21]3)=[O:12])([CH3:8])([CH3:9])[CH3:7]

Participants

5

Reactant 3

HCID 61147Bromoacetyl bromideHCID 81531DiisopropylethylamineHCID 58147578HCID 58147578, compound

Product 1

HCID 66925877HCID 66925877, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Bromoacetyl bromide (0.137 ml) was added to a stirred solution of the product of example 95 (500 mg) and DIPEA (0.425 ml) in dichloromethane (20 ml) over a period of 6 h. The reaction mixture was concentrated in vacuo.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-38997c412dae49d8a4191803f98bdd7b
Source dataset
uspto-grants-2013_03
Patent number
US08394789B2

Reaction notes

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