反应详情

A mixture of 4-chloro-3-nitrophenol (25 g), N,N-dimethylformamide (200 mL), potassium carbonate (60 g) and bromoacetic acid methyl ester (15.5 mL) was stirred at room temperature for 2.5 hours. The mixture was partitioned between ethyl acetate and water, and the aqueous phase extracted with ethyl acetate. The combined extracts were dried over sodium sulfate and then concentrated under reduced pressure. The residue was washed with diethyl ether to afford title compound as a white solid (30 g).

1. customThe mixture was partitioned between ethyl acetate and water
2. extractionthe aqueous phase extracted with ethyl acetate
3. dry with materialThe combined extracts were dried over sodium sulfate
4. concentrationconcentrated under reduced pressure
5. washThe residue was washed with diethyl ether