Potassium Carbonate → HCID 63802187, compound

HRID 1944383Notes

Reaction equation

HRID 1944383 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[F:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1F)[CH:19]=[O:20]>CN(C)C=O>[F:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[S:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[CH:19]=[O:20]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 677894-FluorothiophenolHCID 5880883,4-Difluorobenzaldehyde

Product 1

HCID 63802187HCID 63802187, compoundYield 10.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 4-fluorobenzenethiol (0.93 g), potassium carbonate (3.1 g) and N,N-dimethylformamide (25 mL) was treated with 3,4-difluorobenzaldehyde (1.0 g), and the resulting mixture was stirred at room temperature for 16 hours. The mixture was partitioned between water and ethyl acetate, and the organic phase was dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a colourless gum (0.18 g).

Workup

  1. customThe mixture was partitioned between water and ethyl acetate
  2. dry with materialthe organic phase was dried over magnesium sulfate
  3. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-842f63036d7040c1a2b14e36176edca7
Source dataset
uspto-grants-2013_03
Patent number
US08394836B2

Reaction notes

Loading…