反应详情

温度

-10 °C

A mixture of triethylsilane (0.71 g), trifluoroacetic acid (0.53 g) and 1,2-dichloroethane (2.0 mL) at −10° C. was treated dropwise with a mixture of (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester (0.091 g), 2-benzenesulfonylbenzaldehyde (0.12 g) and 1,2-dichloroethane (3.0 mL), and the resulting mixture was stirred at −10° C. for 15 minutes and then at room temperature for 2 hours. The mixture was diluted with dichloromethane, washed with saturated aqueous sodium hydrogen carbonate solution and dried over magnesium sulfate. The solvent was removed under reduced pressure and the residue purified by column chromatography on silica gel, eluting with a mixture of cyclohexane and dichloromethane (1:1 to 0:1 by volume) to afford the title compound as a colourless gum (0.17 g).

1. waitat room temperature for 2 hours
2. washwashed with saturated aqueous sodium hydrogen carbonate solution
3. dry with materialdried over magnesium sulfate
4. customThe solvent was removed under reduced pressure
5. customthe residue purified by column chromatography on silica gel
6. washeluting with a mixture of cyclohexane and dichloromethane (1:1 to 0:1 by volume)