反应详情

To a solution of methyl 2-chloro-6-[methyl(pyridin-3-ylsulfonyl)amino]isonicotinate (3.12 g, 9.13 mmol) in 1:1 MeOH:THF (60 mL total) was added 1N NaOH solution (27 mL, 27.4 mmol). After 1 h, reaction was concentrated in vacuo. Reaction was diluted with EtOAc (100 mL) and acidified with 1N HCl (50 mL) solution. The aqueous solution was extracted with EtOAc (100 mL×3). The combined organics were washed with brine (100 mL), dried over Mg2SO4, filtered, and concentrated in vacuo to give 2.63 g (88%) of 2-chloro-6-[methyl(pyridin-3-ylsulfonyl)amino]isonicotinic acid as a white solid. LC/MS [M+H]+=328.1.

1. customreaction
2. concentrationwas concentrated in vacuo
3. customReaction
4. extractionThe aqueous solution was extracted with EtOAc (100 mL×3)
5. washThe combined organics were washed with brine (100 mL)
6. dry with materialdried over Mg2SO4
7. filtrationfiltered
8. concentrationconcentrated in vacuo