Benzyl Bromide → HCID 66995933, compound

HRID 1945215Notes

Reaction equation

HRID 1945215 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[CH:5][C:6]([F:10])=[C:7]([OH:9])[CH:8]=1.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:10][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:11])[F:12])=[CH:8][C:7]=1[O:9][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 5188882-Fluoro-5-(trifluoromethyl)phenol

Product 1

HCID 66995933HCID 66995933, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-(trifluoromethyl)-2-fluorophenol (2.0 g), benzyl bromide (1.45 ml) and potassium carbonate (1.65 g) in dry DMF (20 ml) was stirred at RT overnight. The mixture was quenched with water and the solid filtered and dried, yield 2.20 g.

Workup

  1. customThe mixture was quenched with water
  2. filtrationthe solid filtered
  3. customdried

Sources & evidence

ORD record
ord-72c0e32249e14f6187a663408cc664bc
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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