反应详情

To a mixture of the compound of Example 77 (200 mg, 0.423 mmol), triethylamine (122 μL, 0.880 mmol) and THF (10 mL) was added acetoxyacetyl chloride (47.3 μL, 0.440 mmol) at 0° C., and the mixture was stirred at room temperature for 15 hr. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by aminosilica gel chromatography (eluate; ethyl acetate), and the obtained solid was recrystallized from ethyl acetate-THF to give the title compound (171 mg, 75%) as a white powder.

1. washwashed with water and saturated brine
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by aminosilica gel chromatography (eluate; ethyl acetate)
5. customthe obtained solid was recrystallized from ethyl acetate-THF