4-Methylmorpholine → HCID 86761782, compound

HRID 1950700Notes

Reaction equation

[CH2:1]1[CH2:5][N:4]([P+:6]([O:17][N:18]2[N:26]=[N:25][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]2=3)([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[N:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[F:27][P-:28]([F:33])([F:32])([F:31])([F:30])[F:29].[CH3:34][N:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1>>[CH2:1]1[CH2:5][N:4]([P+:6]([O:17][N:18]2[N:26]=[N:25][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]2=3)([N:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)[N:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[CH2:3][CH2:2]1.[F:27][P-:28]([F:33])([F:32])([F:31])([F:30])[F:29].[CH3:34][N:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1

Participants

Reactant 2

HCID 79724-Methylmorpholine

HCID 2724699PyBOP

Product 1

HCID 86761782HCID 86761782, compound

Procedure

To the resin were added Fmoc-amino acid (6 equiv, 0.6 M in NMP), PyBOP (6 equiv, 0.67 M in NMP) and NMM (12 equiv, 33% solution in NMP). The coupling reaction was performed for 90 min with occasional shaking and at the end of the coupling the resin was washed with NMP (6×0.8 ml).

Workup

customThe coupling reaction
washwas washed with NMP (6×0.8 ml)

Sources & evidence

ORD record: ord-9c3f1fbbacf4489084d375ab92a7d76e
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404647B2

Reaction notes

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