Triethylamine → HCID 25104170, compound

To a solution of tetrahydro-4H-pyran-4-one (1.0 g, 10 mmol) in methanol (60 ml) was added ethylamine hydrochloride (815 mg, 10 mmol), 1 ml of NEt3, and 10% Pd on C (350 mg). The mixture was hydrogenated at room temperature over night (18 hours). The solids were filtered, washed with methanol (20 ml) and concentrated under vacuum. The residue was dissolved in chloroform (70 ml) and NEt3 (2 ml) and a solution of [2,1,3]-benzoxadiazole-5-carbonylchloride (600 mg, 3.28 mmol) in chloroform (10 ml) was added slowly. After stirring for 0.5 h, the mixture was washed with water (100 ml) and H2SO4 (→pH 2) and NaHCO3 solution (100 ml). The aqueous was extracted with chloroform (100 ml) and the combined organics were dried over MgSO4 and concentrated under vacuum to give an oil. Chromatography on silica gel eluting with ethyl acetate/hexane (75:25) and chloroform/acetone (85:15), gave white solid after crystallization from diethyl ether (470 mg). Mp=102-4° C., LC-MS, MH+=276; 1H NMR (300 MHz, CDCl3, 2 rotamers) δ 7.93 (d, 1H, J=9.0 Hz); 7.80 (s, 1H); 7.38 (d, 1H, J=9.0 Hz); 4.75-4.45 and 4.15-3.90 and 3.75-3.05 (m+m+m, 7H); 2.04-1.05 ppm (m, 7H).

1. waitThe mixture was hydrogenated at room temperature over night
2. custom(18 hours)
3. filtrationThe solids were filtered
4. washwashed with methanol (20 ml)
5. concentrationconcentrated under vacuum
6. dissolutionThe residue was dissolved in chloroform (70 ml)
7. washthe mixture was washed with water (100 ml) and H2SO4 (→pH 2) and NaHCO3 solution (100 ml)
8. extractionThe aqueous was extracted with chloroform (100 ml)
9. dry with materialthe combined organics were dried over MgSO4
10. concentrationconcentrated under vacuum
11. customto give an oil
12. customafter crystallization from diethyl ether (470 mg)

ORD record

ord-d73802735d2b4961b570d63b3d944717

Source dataset

uspto-grants-2013_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08404682B2