Hydrochloric Acid → HCID 68691867, compound

HRID 1951756Notes

Reaction equation

HRID 1951756 reaction equation
Cl.[CH2:2]([C:5]1([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)[CH2:14][CH2:13][C:8]2(OCC[O:9]2)[CH2:7][CH2:6]1)[CH:3]=[CH2:4].C(=O)([O-])O.[Na+].ClCCl>CC(C)=O.O>[CH2:2]([C:5]1([NH:15][CH2:16][C:17]2[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=2)[CH2:14][CH2:13][C:8](=[O:9])[CH2:7][CH2:6]1)[CH:3]=[CH2:4]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 516892Sodium BicarbonateHCID 68694368HCID 68694368, compound

Product 1

HCID 68691867HCID 68691867, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

Concentrated hydrochloric acid (0.5 ml) was added to a solution of (8-allyl-1,4-dioxaspiro[4.5]dec-8-yl)-(4-methoxybenzyl)amine (C-9) (1.0 g, 3.15 mmol) in acetone (10 ml) and water (0.5 liter), and the mixture was stirred for 16 h at room temperature. Then saturated sodium hydrogen carbonate solution (40 ml) was added to the solution, and extraction with dichloromethane (3×40 ml) was carried out. The combined organic phases were dried with sodium sulfate and concentrated in vacuo.

Workup

  1. dry with materialThe combined organic phases were dried with sodium sulfate
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-24295b7023754075a01901c7dedb5a8c
Source dataset
uspto-grants-2013_03
Patent number
US08404740B2

Reaction notes

Loading…