反应详情

A mixture of 3-Ethyl-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carboxylic acid methyl ester (140 mg, 0.44 mmol), lithium hydroxide monohydrate (180 mg, 4.38 mmol), THF (4 mL) and water (5 mL) was stirred 15 h, acidified with 1N HCl and extracted with EtOAc (×3). The organic extracts were combined, washed with brine, dried over sodium sulfate, filtered and evaporated to give the title compound, 145.4 (100%). MS m/e 305.9 (M+H+).

1. extractionextracted with EtOAc (×3)
2. washwashed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated