反应详情

A mixture of 3-Cyano-5-[(1H-indazol-4-ylmethyl)-carbamoyl]-thiophene-2-carboxylic acid methyl ester (262.7 mg, 0.77 mmol), lithium hydroxide monohydrate (250 mg, 6.17 mmol), THF (8 mL) and water (10 mL) was stirred 4 h, acidified with 1N HCl and extracted with EtOAc (×3). The organic extracts were combined, washed with brine, dried over sodium sulfate, filtered and evaporated to give the title compound, 0.1369 g (54%). MS m/e 327.0 (M+H+).

1. extractionextracted with EtOAc (×3)
2. washwashed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated