Hydrochloric Acid → HCID 88177687, compound

HRID 1952794Notes

Reaction equation

HRID 1952794 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:39])[CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH:19]=[O:20])=[O:9].C(O)C>C(OCC)(=O)C>[ClH:1].[CH3:39][N:3]([CH3:2])[CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH:19]=[O:20])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 53763132HCID 53763132, compound

Product 1

HCID 88177687HCID 88177687, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid--ethyl acetate solution (0.19 ml) was added to a solution of [2-[[N-[3-(dimethylamino)propyl]carbamoyloxy]methyl]phenyl]-N-octadecylformamide (0.20 g) in ethyl acetate (4 ml) while being cooled with ice. After being stirred for 10 minutes, the deposited crystals were dissolved with ethanol and the solution was concentrated. The residue was recrystallized from ethyl acetate, thereby yielding 0.21 g of the aimed compound as white crystals.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationthe solution was concentrated
  3. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-d2b7441224ed4d75840fcf63bcb8e76d
Source dataset
uspto-grants-2000_09
Patent number
US06114325

Reaction notes

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