Hydrochloric Acid → HCID 88178182, compound

HRID 1952799Notes

Reaction equation

HRID 1952799 reaction equation
[ClH:1].[O:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH:23]=[O:24])=[O:13])[CH2:4][CH2:3]1>C(OCC)(=O)C>[ClH:1].[O:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH:23]=[O:24])=[O:13])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53918373HCID 53918373, compound

Product 1

HCID 88178182HCID 88178182, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid--ethyl acetate solution (0.26 ml) was added to a solution of [2-[[N-(3-morpholinopropyl)carbamoyloxy]methyl]phenyl]-N-octadecylformamide (0.30 g) in ethyl acetate (4 ml) at room temperature. After being stirred for 10 minutes, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate-ethanol mixed solvent, thereby yielding 0.27 g of the aimed compound as white crystals.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized from ethyl acetate-ethanol mixed solvent

Sources & evidence

ORD record
ord-9201291041e94bb0aa47f1192a7a0969
Source dataset
uspto-grants-2000_09
Patent number
US06114325

Reaction notes

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