Hydrochloric Acid → HCID 88177700, compound

HRID 1952802Notes

Reaction equation

HRID 1952802 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:36])[NH:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:16]=[O:17])=[O:6]>C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]([CH3:36])[NH:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:16]=[O:17])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53723257HCID 53723257, compound

Product 1

HCID 88177700HCID 88177700, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid--ethyl acetate solution (0.11 ml) was added to a solution of [2-[[N-(dimethylamino)carbamoyloxy]methyl]phenyl]-N-octadecylformamide (0.200 g) in ethyl acetate (6 ml) while being cooled with ice. After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate-ethanol mixed solvent, thereby yielding 0.195 g of the aimed compound as white crystals.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized from ethyl acetate-ethanol mixed solvent

Sources & evidence

ORD record
ord-4641cc037c024abb8aa93c8e59dee5db
Source dataset
uspto-grants-2000_09
Patent number
US06114325

Reaction notes

Loading…