Hydrochloric Acid → HCID 88176874, compound

HRID 1952804Notes

Reaction equation

HRID 1952804 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:39])[CH2:4][CH2:5][CH2:6][N:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][O:17][C:18](=[O:38])[NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:8]=[O:9]>C(OCC)(=O)C>[ClH:1].[CH3:39][N:3]([CH3:2])[CH2:4][CH2:5][CH2:6][N:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][O:17][C:18](=[O:38])[NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:8]=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56992840HCID 56992840, compound

Product 1

HCID 88176874HCID 88176874, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid--ethyl acetate solution (0.35 ml) was added to a solution of N-[3-(dimethylamino)propyl]-{2-[(N-octadecylcarbamoyloxy)methyl]phenyl}formamide (0.49 g) in ethyl acetate (10 ml) at room temperature. After being stirred for 5 minutes, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate, thereby yielding 0.41 g of the aimed compound as white crystals.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-4008010ea445409c9e17abe4b1e30ebf
Source dataset
uspto-grants-2000_09
Patent number
US06114325

Reaction notes

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