Hydrochloric Acid → HCID 23299378, compound

HRID 1952813Notes

Reaction equation

HRID 1952813 reaction equation
[ClH:1].[OH:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:21](=[O:41])[NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[O:12])[CH2:7][CH2:6]1>C(OCC)(=O)C>[ClH:1].[CH2:23]([NH:22][C:21]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][O:13][C:11]([N:8]1[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][OH:2])[CH2:6][CH2:7]1)=[O:12])=[O:41])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15484867HCID 15484867, compound

Product 1

HCID 23299378HCID 23299378, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid--ethyl acetate solution (0.40 ml) was added to a solution of [2-(N-octadecylcarbamoyl)phenyl]methyl 4-(2-hydroxyethyl)piperazinecarboxylate (0.45 g) in ethyl acetate (10 ml) at room temperature. After being stirred for 10 minutes, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate-ethanol mixed solvent, thereby yielding 0.39 g of the aimed compound as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized from ethyl acetate-ethanol mixed solvent

Sources & evidence

ORD record
ord-e4280b6f3958423c97366694add6ec77
Source dataset
uspto-grants-2000_09
Patent number
US06114325

Reaction notes

Loading…