Dichloromethane → HCID 86755815, compound

HRID 1953034Notes

Reaction equation

HRID 1953034 reaction equation
ClCCl.[NH2:4][C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17]C(OC(C)(C)C)=O)=[CH:12][CH:11]=1)=[O:6].[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>O1CCCC1>[NH2:4][C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH2:17])=[CH:12][CH:11]=1)=[O:6].[F:25][C:26]([F:31])([F:30])[C:27]([O-:29])=[O:28]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 23301851HCID 23301851, compound

Product 1

HCID 86755815HCID 86755815, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 61e), but using tetrahydrofuran as solvent instead of dichloromethane, from 4-[2-(aminocarbonylamino)ethyl]-N-[(1,1-dimethylethoxy)carbonyl]benzenemethanamine and trifluoroacetic acid in a yield of 61% of theory. Colourless crystals, which were used in the following step without total purification.

Workup

  1. customPrepared analogously to Example 61e), but
  2. customColourless crystals, which were used in the following step without total purification

Sources & evidence

ORD record
ord-6e8a098219884666bf1e1ed5035002a7
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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