Hydrochloric Acid → HCID 23301809, compound

HRID 1953035Notes

Reaction equation

[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1)#[N:2].[ClH:11].CN.[C:14]([BH3-])#[N:15].[Na+].Cl>>[ClH:11].[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH2:7][NH:15][CH3:14])=[CH:5][CH:4]=1)#[N:2]

Participants

Reactant 4

HCID 313Hydrochloric Acid2×

HCID 660424-Cyanobenzaldehyde

HCID 5003444Sodium cyanoborohydride

HCID 6364545Methylamine hydrochloride

Product 1

HCID 23301809HCID 23301809, compoundYield 52%

Procedure

Prepared analogously to Example 61a) from 4-cyanobenzaldehyde, methylamine-hydrochloride and sodium cyanoborohydride. The resulting base was converted into the corresponding hydrochloride by treating the methanolic solution with ethereal hydrogen chloride. Yield: 52% of theory. Colourless crystals.

Sources & evidence

ORD record: ord-09ea623f92574d4c897c964bc7a640a3
Source dataset: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06114390

Reaction notes

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