Potassium Carbonate → HCID 23294434, compound

HRID 1955245Notes

Reaction equation

HRID 1955245 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15]([OH:19])=[CH:16]2)=[CH:11][CH:10]=1)[C:2]1C=CC=CC=1.[CH2:20]([CH:27]1[CH2:32][CH2:31][N:30](C(=O)CBr)[CH2:29][CH2:28]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[CH2:20]([CH:27]1[CH2:32][CH2:31][N:30]([CH2:2][CH2:1][O:8][C:9]2[CH:18]=[C:17]3[C:12](=[CH:11][CH:10]=2)[CH:13]=[CH:14][C:15]([OH:19])=[CH:16]3)[CH2:29][CH2:28]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27638187-(Benzyloxy)naphthalen-2-olHCID 22320730HCID 22320730, compound

Product 1

HCID 23294434HCID 23294434, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared from 7-benzyloxy-naphthalen-2-ol (1.00 g, 4.00 mmol), 1-(4-benzyl-piperidin-1-yl)-2-bromo-ethanone (1.20 g, 4.05 mmol) and potassium carbonate (1.10 g, 7.96 mmol) in tetrahydofuran (40 ml) in three steps as a solid, mp 159-160° C. Analysis calculated for C24H27NO2 ·0.16H2O: C, 79.11; H, 7.56; N, 3.85. Found: C, 79.11; H. 7.63; N, 3.83.

Sources & evidence

ORD record
ord-20fa12c1c0384c1ea4c11de886bde26c
Source dataset
uspto-grants-2000_09
Patent number
US06124323

Reaction notes

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