Ethyl Acetate → HCID 54397117, compound

To a solution of 2-trimethylsilylethanethiol (0.86 g, 6.41 mmol), synthesis described by Anderson, Ranasinghe, Palmer, and Fuchs, above) in THF (10 mL) was added sodium hydride (0.256 g, 6.41 mmol as a 60% mineral oil dispersion). The mixture was stirred for 10 minutes. Boc-homophenylalaninol mesylate (2.00 g, 5.82 mmol, synthesis described in Example 13, above) was added. The solution was stirred for 2 hours. Ethyl acetate (50 mL) was added. The solution was washed with 30 mL each of 1M HCl, saturated aqueous sodium bicarbonate, and brine, dried over MgSO4, filtered, and the solvent was removed under reduced pressure, giving the intermediate (S)-2-tert-butoxycarbonylamino-4-phenylbutyl trimethylsilylethyl sulfide. TLC: (5% ethyl acetate/hexane) Rf =0.22. This material was dissolved in CH2Cl2 (50 mL), cooled to -10° C., and treated with 4-chloroperbenzoic acid (3.24 g, 12.22 mmol, estimated 65% peracid content). The mixture was stirred overnight. The suspension was filtered, and saturated aqueous NaHSO3 (40 mL) and saturated aqueous sodium bicarbonate (50 mL) were carefully added to the filtrate. The organic phase was separated, dried over MgSO4, filtered, and the solvent was removed under reduced pressure to give the product, Boc-Hph-β-SO2CH2CH2TMS in quantitative mass recovery from the mesylate. TLC: (30% ethyl acetate/hexane) Rf =0.49.

1. stirringThe solution was stirred for 2 hours
2. washThe solution was washed with 30 mL each of 1M HCl, saturated aqueous sodium bicarbonate, and brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customthe solvent was removed under reduced pressure

ORD record

ord-5869beb2de0646b48683ce6407f52446

Source dataset

uspto-grants-1998_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05776718