Water → 2-(3-chloropropoxy)aniline

HRID 1955867Notes

Reaction equation

HRID 1955867 reaction equation
[H-].[Na+].[NH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10].[Cl:11][CH2:12][CH2:13][CH2:14]Br.O>CN(C)C=O>[Cl:11][CH2:12][CH2:13][CH2:14][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[NH2:3]

Participants

6

Reactant 4

HCID 962WaterHCID 58012-AminophenolHCID 80061-Bromo-3-chloropropaneHCID 24758Sodium hydride

Product 1

HCID 100126432-(3-chloropropoxy)anilineYield 12.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent3×

Procedure

To a stirred suspension of sodium hydride (11.0 g, 230 mmol of a 50% oil dispersion) in dimethylformamide (250 ml), under nitrogen, was added, dropwise, 2-aminophenol (25.0 g, 230 mmol) dissolved in dimethylformamide (125 ml). After complete addition, the reaction was stirred at ambient temperature for 1 hour, and then it was cooled to 5° C. (ice bath). 3-Chloro-1-bromopropane (36.2 g, 230 mmol) in dimethylformamide (50 ml) was added, dropwise, so that the temperature did not go above 8° C. The reaction was stirred for 4 hours and then permitted to stand at ambient temperature for 16 hours. The reaction was poured into water and extracted with ethyl acetate. The ethyl acetate was washed (water), dried (MgSO4), and the solvent concentrated to afford 25.4 g of a reddish, dark oil. About 12.0 g of the oil was chromatographed on HPLC columns. Concentration of the largest fractions gave 5.4 g of 2-(3-chloropropoxy) aniline as an oil.

Workup

  1. additionunder nitrogen, was added
  2. additionAfter complete addition
  3. temperatureit was cooled to 5° C. (ice bath)
  4. customdid not go above 8° C
  5. stirringThe reaction was stirred for 4 hours
  6. waitto stand at ambient temperature for 16 hours
  7. extractionextracted with ethyl acetate
  8. washThe ethyl acetate was washed (water)
  9. dry with materialdried (MgSO4)
  10. concentrationthe solvent concentrated
  11. customto afford 25.4 g of a reddish, dark oil
  12. customAbout 12.0 g of the oil was chromatographed on HPLC columns

Sources & evidence

ORD record
ord-3836c8991f6a413c975328e67427899b
Source dataset
uspto-grants-1998_07
Patent number
US05776963

Reaction notes

Loading…