Piperazine → HCID 22375413, compound

HRID 1956144Notes

Reaction equation

HRID 1956144 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:7]([O:9][C:10]1[CH:18]=[C:17]2[C:13]([CH2:14][CH2:15][C:16]2=O)=[CH:12][CH:11]=1)[CH3:8].[BH4-].[Na+]>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-]>[CH2:7]([O:9][C:10]1[CH:18]=[C:17]2[C:13]([CH2:14][CH2:15][CH:16]2[N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:12][CH:11]=1)[CH3:8]

Participants

5

Reactant 3

HCID 4837PiperazineHCID 4311764Sodium borohydrideHCID 150391526-Ethoxy-2,3-dihydro-1H-inden-1-one

Product 1

HCID 22375413HCID 22375413, compound

Reagents, catalysts & solvents 1

HCID 11026Titanium isopropoxideCatalyst

Procedure

Piperazine (19.8 g, 0.23 mol), 6-ethoxyindan-1-one (4.00 g, 23 mmol), titanium(IV) isopropoxide (15.3 ml, 46 mmol) and sodium borohydride (2.7 g, 71 mmol) were reacted by Method A to give the product which was converted to the fumurate salt (beige solid, 5.7 g, 68.5%, mp: 142°-147° C.). Calcd for C15H22N2O.C4H4O4 : C, 62.97%; H, 7.23%; N, 7.73%. Found: C. 62.88%; H, 7.22%; N, 7.48%.

Workup

  1. customto give the product which

Sources & evidence

ORD record
ord-75db16f29d95429baf1d8cb9f788df60
Source dataset
uspto-grants-1998_07
Patent number
US05780470

Reaction notes

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