Hydrochloric Acid → 1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperazin-1-yl]ethyl}-3-ethylimidazolidin-2-one

HRID 1956354Notes

Reaction equation

HRID 1956354 reaction equation
FC1C=CC2C(C3CCN([CH2:15][CH2:16][N:17]4[CH2:21][CH2:20][N:19]([CH:22](C)[CH3:23])[C:18]4=[O:25])CC3)=NOC=2C=1.[F:28][C:29]1[CH:43]=[CH:42][C:32]2[C:33]([N:36]3[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]3)=[N:34][O:35][C:31]=2[CH:30]=1.BrCC.Cl>>[F:28][C:29]1[CH:43]=[CH:42][C:32]2[C:33]([N:36]3[CH2:41][CH2:40][N:39]([CH2:15][CH2:16][N:17]4[CH2:21][CH2:20][N:19]([CH2:22][CH3:23])[C:18]4=[O:25])[CH2:38][CH2:37]3)=[N:34][O:35][C:31]=2[CH:30]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6332Ethyl BromideHCID 109268541-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}-3-isopropylimidazolidin-2-oneHCID 19805377HCID 19805377, compound

Product 1

HCID 186632021-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperazin-1-yl]ethyl}-3-ethylimidazolidin-2-one

Procedure

This product is prepared in the same manner as the compound of Example 1 but using 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperazine instead of 4-(6-fluoro-1,2-benzisoxazol-3-yl)-piperidine in Step 1, and using bromoethane instead of 2-bromopropane in Step 2. The hydrochloride of the title compound so obtained melts at 201°-204° C.

Sources & evidence

ORD record
ord-a80eeb76fe8c4f4c971cfb86a5cf5390
Source dataset
uspto-grants-1998_07
Patent number
US05780474

Reaction notes

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