Water → HCID 19605591, compound

HRID 1956460Notes

Reaction equation

HRID 1956460 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([C:13]([O:15]CC)=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Li+].[OH-].O>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([C:13]([OH:15])=[O:14])[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 18663250HCID 18663250, compound

Product 1

HCID 19605591HCID 19605591, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A solution of the above ester (10 g, 42.7 mmol) in THF (50 mL) was treated with 1N LiOH (47 mL, 47.0 mmol) and H2O (50 mL). The resulting solution was concentrated and the aqueous residue cooled to 0° C., then adjusted to pH≈6 with 1N HCl and the resulting solid 8-1, collected by filtration.

Workup

  1. concentrationThe resulting solution was concentrated
  2. filtrationthe resulting solid 8-1, collected by filtration

Sources & evidence

ORD record
ord-82ff4110022c4127a3096d4f2dfbd88a
Source dataset
uspto-grants-1998_07
Patent number
US05780480

Reaction notes

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