Aniline → Phenylurea

HRID 1956614Notes

Reaction equation

HRID 1956614 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10]C1C=CC=CC=1>CN(C)C=O>[C:1]1([NH:7][C:8](=[O:9])[NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 7672Phenyl isocyanate

Product 1

HCID 6145Phenylurea

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of phenyl isocyanate (1.0 equiv.) in dimethyl formamide (1 mL) the corresponding aniline (1.0 equiv.) was added. The reaction mixture was stirred at about 80° C. until complete (24-48 hours), then the solvent was removed under vacuum. The purifications, yields and spectral characteristics for each individual compound are listed below.

Workup

  1. customthe solvent was removed under vacuum
  2. customThe purifications, yields

Sources & evidence

ORD record
ord-c960957765c64c04b47f8e5964ab3818
Source dataset
uspto-grants-1998_07
Patent number
US05780483

Reaction notes

Loading…