Dimethylformamide → HCID 19068972, compound

HRID 1957200Notes

Reaction equation

HRID 1957200 reaction equation
O=P(Cl)(Cl)[Cl:3].[CH3:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([CH3:16])=[CH:13][CH:14]=2)[CH2:9][C:8]1=O.CN([CH:21]=[O:22])C>>[CH3:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([CH3:16])=[CH:13][CH:14]=2)[C:9]([CH:21]=[O:22])=[C:8]1[Cl:3]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 14918455HCID 14918455, compound

Product 1

HCID 19068972HCID 19068972, compoundYield 78%

Procedure

Prepared from POCl3 (1.7 ml), DMF (1.6 ml), 1,5-dimethyl-1,3-dihydroindol-2-one (1.0 g) yielding (46) 1.0 g (78%). M.p. 120°-121° C. as crude product sufficiently pure for the next synthesis.

Sources & evidence

ORD record
ord-f28cd284fe8542e1b7843fb7468a8b54
Source dataset
uspto-grants-1998_07
Patent number
US05783575

Reaction notes

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