Water → HCID 178507534, compound

HRID 1959374Notes

Reaction equation

HRID 1959374 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([NH:11][NH2:12])=O)=[N:4][C:5]([Br:8])=[CH:6][N:7]=1.Cl.Cl.[NH2:15][C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19](N)=[NH:20].CC[O-].[Na+].O>CN(C=O)C>[NH2:15][C:16]1[CH:17]=[C:18]([C:19]2[NH:20][C:9]([C:3]3[C:2]([NH2:1])=[N:7][CH:6]=[C:5]([Br:8])[N:4]=3)=[N:11][N:12]=2)[CH:22]=[CH:23][CH:24]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2723922Sodium ethoxideHCID 30846513-Aminobenzene-1-carboximidamide--hydrogen chloride (1/2)HCID 580702563-Amino-6-bromopyrazine-2-carbohydrazide

Product 1

HCID 178507534HCID 178507534, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3-amino-6-bromo-pyrazine-2-carbohydrazide (5 g, 21.55 mmol), 3-aminobenzamidine dihydrochloride (4.484 g, 21.55 mmol) and NaOEt (4.399 g, 64.65 mmol) were combined in DMF (50.00 mL) and heated to 100° C. in the microwave for 20 min. Water was added and the precipitate collected. Used without further purification. Assumed 100% Yield.

Workup

  1. customthe precipitate collected
  2. customUsed without further purification

Sources & evidence

ORD record
ord-c8ec119755e74a39a12cbe4979f73bc0
Source dataset
uspto-grants-2013_04
Patent number
US08410112B2

Reaction notes

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