Dimethylformamide → 4-[3-(4-Chlorobenzyl)-6-(2,2-difluoroethoxy)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde
Reaction equation
[Br:26][CH2:27][c:28]1[cH:29][cH:30][c:31]([Cl:34])[cH:32][cH:33]1.[C:35](=[O:36])([O-:37])[O-:38].[CH3:41][CH2:42][O:43][C:44]([CH3:45])=[O:46].[Cs+:39].[Cs+:40].[F:1][CH:2]([CH2:3][O:4][c:5]1[cH:6][c:7]2[c:8](=[O:24])[nH:9][c:10](=[O:23])[n:11]([CH:15]3[CH2:16][CH2:17][N:18]([CH:21]=[O:22])[CH2:19][CH2:20]3)[c:12]2[cH:13][cH:14]1)[F:25].[O:47]=[CH:48][N:49]([CH3:50])[CH3:51]>>[F:1][CH:2]([CH2:3][O:4][c:5]1[cH:6][c:7]2[c:8](=[O:24])[n:9]([CH2:27][c:28]3[cH:29][cH:30][c:31]([Cl:34])[cH:32][cH:33]3)[c:10](=[O:23])[n:11]([CH:15]3[CH2:16][CH2:17][N:18]([CH:21]=[O:22])[CH2:19][CH2:20]3)[c:12]2[cH:13][cH:14]1)[F:25]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-e2194981dd6b493cb36aa5f8f44826b4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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