Triethylamine → HCID 57820161, compound

HRID 1966399Notes

Reaction equation

HRID 1966399 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:16]2[C:20]3[N:21]=[C:22]([NH:25][C:26]4[CH:31]=[CH:30][C:29]([CH3:32])=[C:28]([CH2:33][N:34]5[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]5)[CH:27]=4)[N:23]=[CH:24][C:19]=3[CH:18]=[CH:17]2)[CH:5]=[C:6]([F:15])[C:7]=1[CH2:8][N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1.[N+](C1C=C[C:46]([O:49]C=O)=CC=1)([O-])=O.C(N(CC)CC)C>C1COCC1>[F:15][C:6]1[CH:5]=[C:4]([N:16]2[C:20]3[N:21]=[C:22]([NH:25][C:26]4[CH:31]=[CH:30][C:29]([CH3:32])=[C:28]([CH:27]=4)[CH2:33][N:34]4[CH2:39][CH2:38][N:37]([CH:46]=[O:49])[CH2:36][CH2:35]4)[N:23]=[CH:24][C:19]=3[CH:18]=[CH:17]2)[CH:3]=[C:2]([F:1])[C:7]=1[CH2:8][N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 746284-Nitrophenyl formateHCID 57820361HCID 57820361, compound

Product 1

HCID 57820161HCID 57820161, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound is obtained by treating [7-(3,5-difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-methyl-3-piperazin-1-ylmethyl-phenyl)-amine (Example 332) with formic acid 4-nitro-phenyl ester in presence of triethylamine in THF. HPLC: tR=6.84 min (Method B); MS-ES: (M+H)+=562

Workup

  1. customThe compound is obtained

Sources & evidence

ORD record
ord-f668ecaa588f448b89fbaa0ebea4b37c
Source dataset
uspto-grants-2013_04
Patent number
US08420657B2

Reaction notes

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