反应详情

温度

80 °C

At room temperature, [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (9.7 mg), potassium vinyltrifluoroborate (10.6 mg) and triethylamine (0.010 mL) were added in that order to an n-propanol (1.0 mL) solution of the compound (30.0 mg) obtained in Example 106, and stirred at 80° C. for 10 hours. After left cooled, ethyl acetate was added to the reaction liquid, then washed three times with water, and dried with sodium sulfate. The drying agent was removed through filtration, and the solvent was evaporated off under reduced pressure. The residue was purified through silica gel column chromatography (NH Biotage Column, ethyl acetate/hexane=from 0% to 80%, gradient) to give the entitled compound (11.0 mg, 42%) as a colorless oily substance.

1. waitAfter left
2. temperaturecooled
3. washwashed three times with water
4. dry with materialdried with sodium sulfate
5. customThe drying agent was removed through filtration
6. customthe solvent was evaporated off under reduced pressure
7. customThe residue was purified through silica gel column chromatography (NH Biotage Column, ethyl acetate/hexane=from 0% to 80%, gradient)