Sodium hydride → HCID 23642189, compound

HRID 1968390Notes

Reaction equation

HRID 1968390 reaction equation
[CH2:1]([S:3][C:4]1[S:8][C:7]([SH:9])=[N:6][N:5]=1)[CH3:2].[H-].[Na+].Cl[C:13]1[C:14]([C:19]#[N:20])=[N:15][CH:16]=[CH:17][N:18]=1>CN(C=O)C.C1C=CC=CC=1>[CH2:1]([S:3][C:4]1[S:8][C:7]([S:9][C:13]2[C:14]([C:19]#[N:20])=[N:15][CH:16]=[CH:17][N:18]=2)=[N:6][N:5]=1)[CH3:2]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 2924653-Chloropyrazine-2-carbonitrileHCID 178477366HCID 178477366, compound

Product 1

HCID 23642189HCID 23642189, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

The title compound was prepared according to the procedure described in Example 1 by using 5-(ethylthio)-1,3,4-thiadiazole-2-thiol (592 mg, 3.33 mmol), NaH (60% dispersion in mineral oil, 146 mg, 3.66 mmol), and 3-chloropyrazine-2-carbonitrile (422 mg, 3.02 mmol) in DMF and benzene (8 ml, 1/1) by stirring at 90° C. under nitrogen atmosphere overnight.

Sources & evidence

ORD record
ord-fbe4e919e3a5458cb43d6898cbf51c9a
Source dataset
uspto-grants-2013_04
Patent number
US08426358B2

Reaction notes

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