Sodium hydride → HCID 23659326, compound

HRID 1968396Notes

Reaction equation

HRID 1968396 reaction equation
[CH2:1]([S:13][C:14]1[S:18][C:17]([SH:19])=[N:16][N:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[H-].[Na+].Cl[C:23]1[C:24]([C:29]#[N:30])=[N:25][CH:26]=[CH:27][N:28]=1>CN(C=O)C.C1C=CC=CC=1>[CH2:1]([S:13][C:14]1[S:18][C:17]([S:19][C:23]2[C:24]([C:29]#[N:30])=[N:25][CH:26]=[CH:27][N:28]=2)=[N:16][N:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 2924653-Chloropyrazine-2-carbonitrileHCID 178443318HCID 178443318, compound

Product 1

HCID 23659326HCID 23659326, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to Example 1 by using 5-(dodecylthio)-1,3,4-thiadiazole-2-thiol (319 mg, 1.00 mmol), NaH (60% dispersion in mineral oil, 44 mg, 1.10 mmol), and 3-chloropyrazine-2-carbonitrile (140 mg, 1.00 mmol) in DMF and benzene (6 ml, 1/1) by stirring at room temperature under nitrogen atmosphere overnight.

Sources & evidence

ORD record
ord-5cba523c3b8a458cb4573b18edf37f4d
Source dataset
uspto-grants-2013_04
Patent number
US08426358B2

Reaction notes

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