反应详情

A mixture of N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine (1.00 g, 3.45 mmol) and SnCl2.2H2O (3.10 g, 13.8 mmol) in ethyl acetate (35 mL) was refluxed for 2 h and then cooled to room temperature. After its pH was adjusted to 9-10 with 5% aqueous NaHCO3, the mixture was subject to extraction with EtOAc. The combined organic layers were washed with saturated brine and H2O and dried. The solvent was removed under reduced pressure to provide 0.79 g (89%) of N4-(3-ethynylphenyl)quinazoline-4,6-diamine as a yellow solid.

1. temperaturewas refluxed for 2 h
2. extractionthe mixture was subject to extraction with EtOAc
3. washThe combined organic layers were washed with saturated brine and H2O
4. customdried
5. customThe solvent was removed under reduced pressure