Oxalyl chloride → 4-(Bromomethyl)-3-(trifluoromethyl)benzoyl chloride

HRID 1968932Notes

Reaction equation

HRID 1968932 reaction equation
[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13].C(Cl)(=O)C([Cl:19])=O>ClCCl.CN(C=O)C>[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:19])=[O:8])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 231458934-(Bromomethyl)-3-(trifluoromethyl)benzoic acid

Product 1

HCID 251342804-(Bromomethyl)-3-(trifluoromethyl)benzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

1.00 g of 4-(bromomethyl)-3-(trifluoromethyl)benzoic acid was dissolved in dichloromethane (q.s.), then 2 drops of anhydrous N,N′-dimethylformamide were added. Then 2 ml of oxalyl chloride was added dropwise to the mixture. The reaction mixture was reacted at room temperature for 5 h, and concentrated to provide the product.

Workup

  1. customThe reaction mixture was reacted at room temperature for 5 h
  2. concentrationconcentrated
  3. customto provide the product

Sources & evidence

ORD record
ord-a752c49b7ab5411abf8d79bdfeb05638
Source dataset
uspto-grants-2013_04
Patent number
US08426446B2

Reaction notes

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