Methane → HCID 58288533, compound

HRID 1969089Notes

Reaction equation

HRID 1969089 reaction equation
[CH2:1]([O:3][C:4](=[O:38])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][C:16]=2[CH2:24][N:25]([C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[O:29])[CH2:26][CH3:27])[CH:7]=1)[CH3:2].CN(C)N.C>CCO>[CH2:1]([O:3][C:4](=[O:38])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][C:16]=2[CH2:24][N:25]([C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[O:29])[CH2:26][CH3:27])[CH:7]=1)[CH3:2]

Participants

5

Reactant 3

HCID 297MethaneHCID 59761,1-DimethylhydrazineHCID 58288466HCID 58288466, compound

Product 1

HCID 58288533HCID 58288533, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
65 °C

Procedure

(3-{2-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4-nitro-phenoxy}-4-methoxy-phenyl)-acetic acid ethyl ester (0.1 g, 0.19 mmol), 1,1-dimethylhydrazine (0.1 g, 1.3 mmol), ferric chloride (0.01 g), and DARCO (0.05 g) were combined in EtOH (5 mL), and the reaction was stirred at 65° C. until complete. The mixture was worked up to give the title compound.

Sources & evidence

ORD record
ord-4796098ef68b43a4926e0d825d6d11a2
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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