Hydrochloric Acid → HCID 25117629, compound

HRID 1969158Notes

Reaction equation

HRID 1969158 reaction equation
[C:1]([CH2:4][CH2:5][C:6]([NH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13](OC)=[O:14])=[C:11]([OH:19])[CH:10]=1)=[O:7])([OH:3])=[O:2].Cl.[OH-].[NH4+:22]>>[C:1]([CH2:4][CH2:5][C:6]([NH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([NH2:22])=[O:14])=[C:11]([OH:19])[CH:10]=1)=[O:7])([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 25117631HCID 25117631, compound

Product 1

HCID 25117629HCID 25117629, compound

Procedure

Methyl 4-(3-carboxy-propionylamino)-2-hydroxybenzoate (1 g) from Example 2 is dissolved in 5 mL of 28% ammonium hydroxide solution. The reaction mixture is stirred at ambient conditions for 16 hours. In an ice-water bath, the solution is carefully acidified using concentrated hydrochloric acid. The precipitate is collected by filtration, washed with water and dried.

Workup

  1. customIn an ice-water bath, the solution is carefully acidified using concentrated
  2. filtrationThe precipitate is collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-a6dd87129eb940c1abad1ed13aa1bc99
Source dataset
uspto-grants-2013_04
Patent number
US08426466B2

Reaction notes

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