Hydrochloric Acid → α,α-Dimethyl-6-(trifluoromethyl)-2-pyridinemethanol

Temperature

0 °C

Add 6-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (80.0 g, 390 mmol) to a mixture of THF (240 mL) and tert-butylmethyl ether (400 mL). Add the solution slowly to a 3 M methylmagnesium chloride in THF (390 mL, 1.17 moles) and maintain 8° C. to 16° C. Cool the mixture to 0° C. and add a mixture of 5 M hydrochloric acid (257 mL, 1.29 moles) and water (200 mL). Separate the phases and concentrate the organic phase under reduced pressure. Add heptane (160 mL) and cool the mixture to 5° C. Collect the precipitate by vacuum filtration and rinse the solid with heptane (20 mL) followed by pentane (30 mL). Vacuum dry the solid to afford the title compound as a tan solid (72.3 g, 352 mmol, 90%). 1H NMR (400 MHz, DMSO d6) δ 8.04 (t, J=7.7 Hz, 1H), 7.94 (d, J=7.9 Hz, 1H), 7.69 (d, J=7.0 Hz, 1H), 5.40 (s, 1H), 1.43 (s, 6H). HRMS (ESI) m/z (M+H)+ calcd for C9H10F3NO: 206.0787, found 206.0787.

1. temperaturemaintain 8° C. to 16° C
2. additionadd
3. customSeparate the phases
4. concentrationconcentrate the organic phase under reduced pressure
5. temperatureAdd heptane (160 mL) and cool the mixture to 5° C
6. customCollect the precipitate
7. filtrationby vacuum filtration
8. washrinse the solid with heptane (20 mL)
9. customVacuum dry the solid

ORD record

ord-2e4da4f76c7848188e22c8e8b5ed1c8d

Source dataset

uspto-grants-2013_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08426448B2